Squamous Cell Carcinoma Of The Lung Paraneoplastic Syndrome

Though both main types of lung cancer small cell lung cancer sclc about 15 of cases and non small cell lung cancer nsclc around 85 of cases including adenocarcinoma squamous cell carcinoma and large cell carcinoma have been associated with paraneoplastic syndromes they more commonly occur in association with small cell lung cancer which shares a neuroendocrine lineage.

Squamous cell carcinoma of the lung paraneoplastic syndrome.

Sometimes the symptoms of paraneoplastic s. These cells form on the surface of the skin on the lining of hollow organs in the body and on the lining of the respiratory and digestive tracts. Primary tumors of the head and neck most commonly associated with paraneoplastic syndromes include squamous cell carcinoma scc lymphoma thyroid carcinoma thymoma melanoma and paraganglioma. Hypercalcemia refers to an elevated level of calcium in the blood.

The presence of paraneoplastic gbs remains controversial but there are reports of gbs occurring in the presence of different types of cancers including lung cancer 3 10 non lung squamous cell carcinoma gastrointestinal cancers 12 13 bladder cancer and lymphomas 15 16. Here we report a case of a 61 year old man with untreated squamous cell carcinoma of the lung diagnosed with rapidly progressing gbs. Paraneoplastic syndromes are typical among middle aged to older patients and they most commonly present with cancers of the lung breast ovaries or lymphatic system. Squamous cell carcinoma is the most common cause of pancoast syndrome also known as superior sulcus syndrome.

Oat cell carcinoma and scc of the lung are the two most common metastatic tumors to the head and neck that cause these syndromes table 1. Lung cancer facts small cell and epidermoid cancers present as central masses with endobronchial growth adenocarcinomas and large cell cancers present as peripheral nodules masses with pleural involvement. 10 20 of epidermoid and large cell cancers cavitate. Up to 16 of patients with small cell lung.

A paraneoplastic syndrome is a syndrome that is the consequence of cancer in the body specifically due to the production of chemical signalling molecules by tumor cells or by an immune response against the tumor. One of the most common paraneoplastic syndromes associated with lung cancer is the syndrome of inappropriate antidiuretic hormone siadh secretion. Squamous cell can cavitate. Hypercalcemia as a paraneoplastic syndrome occurs most commonly with squamous cell carcinoma of the lungs a form of non small cell lung cancer.